A Molecular Study of Solid Pseudopapillary Neoplasm of the Pancreas in a Pediatric Patient

Vera Lucia Antunes Chagas, Marlon Dias Mariano Santos, Juliana de Saldanha da Gama Fischer, Bruna dos Santos Paiva Ribeiro, Fernando Colonna Rosman, Paulo Costa Carvalho, Danielle FornyForny, Maria da Gloria da Costa Carvalho

Abstract


Solid pseudopapillary neoplasm of the pancreas (SPNP) is considered as a tumor with low malignant potential. Little is known about how its molecular heterogeneity is involved in its pathogenesis. We aim to evaluate tumor heterogeneity by immunohistochemistry (IH) and proteomics in three macroscopically distinct areas. Tumor fragments were obtained from a 12-year-old female patient. We identified by mass spectrometry (MS) 1,427, 5,786, and 4,298 proteins for each sample, 1,337 being common to all fragments. Several MS results were immunohistochemically validated. Our results demonstrate unique intra-tumor protein profiles based on its heterogeneity.




Int J Clin Pediatr. 2018;7(4):63-68
doi: https://doi.org/10.14740/ijcp320


Keywords


Molecular study; Solid pseudopapillary neoplasm of the pancreas; Pediatric patient

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International Journal of Clinical Pediatrics, quarterly, ISSN 1927-1255 (print), 1927-1263 (online), published by Elmer Press Inc.        
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