Int J Clin Pediatr

International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access

Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc

Journal website http://www.theijcp.org

Original Article

Volume 1, Number 2-3, June 2012, pages 55-62

Febrile Seizures With Pandemic (H1N1) 2009 Virus Infection

**Table 1.** Characteristics of FSs in children with 2009 H1N1 influenza infection.
	Pandemic A (H1N1) FS
WBC: white blood cell count; CRP: C-reactive protein.
Total	90
Male	60 (66.7%)
Age (year; mean ± SD)	4.3 ± 2.8
Patients aged ≥ 6 years	23 (25.6%)
Body temperature at seizure occurrence (°C; mean ± SD)	39.3 ± 0.9
Positive history of seizures in first-degree relatives	25 (27.8%)
Time from fever to seizure occurrence
< 24 h (%)	83 (92.2%)
> 24 h (%)	7 (7.8%)
No. of previous febrile seizures
0	41 (45.6%)
1	25 (27.8%)
2	9 (10.0%)
3	4 (4.4%)
4	1 (1.1%)
> 4	3 (3.3%)
Unknown	4 (4.4%)
Seizure manifestation Simple type (%)	82 (91.1%)
Seizure durations
Average (min; mean ± SD)	4.8 ± 8.0
< 5 min	68 (75.6%)
5 - 15 min	7 (7.8%)
15 - 30 min	5 (5.6%)
≥ 30 min	1 (1.1%)
Unknown	9 (10.0%)
Hospitalized patients	12 (13.3%)
Age of hospitalized patients (year; mean±SD)	4.5 ± 2.5
WBC (µl; mean ± SD)	10,520.0 ± 3856.2
CRP (mg/dl; mean ± SD)	0.61 ± 0.87
Positive medications (%)	31 (34.4%)

Table 1. Characteristics of FSs in children with 2009 H1N1 influenza infection.

Pandemic A (H1N1) FS

WBC: white blood cell count; CRP: C-reactive protein.

Total

Male

60 (66.7%)

Age (year; mean ± SD)

4.3 ± 2.8

Patients aged ≥ 6 years

23 (25.6%)

Body temperature at seizure occurrence (°C; mean ± SD)

39.3 ± 0.9

Positive history of seizures in first-degree relatives

25 (27.8%)

Time from fever to seizure occurrence

< 24 h (%)

83 (92.2%)

> 24 h (%)

7 (7.8%)

No. of previous febrile seizures

41 (45.6%)

25 (27.8%)

9 (10.0%)

4 (4.4%)

1 (1.1%)

> 4

3 (3.3%)

Unknown

4 (4.4%)

Seizure manifestation Simple type (%)

82 (91.1%)

Seizure durations

Average (min; mean ± SD)

4.8 ± 8.0

< 5 min

68 (75.6%)

5 - 15 min

7 (7.8%)

15 - 30 min

5 (5.6%)

≥ 30 min

1 (1.1%)

Unknown

9 (10.0%)

Hospitalized patients

12 (13.3%)

Age of hospitalized patients (year; mean±SD)

4.5 ± 2.5

WBC (µl; mean ± SD)

10,520.0 ± 3856.2

CRP (mg/dl; mean ± SD)

0.61 ± 0.87

Positive medications (%)

31 (34.4%)

**Table 2.** Comparison of children with FSs in influenza A (H1N1) pdm, seasonal influenza, and non-influenza infection.
	Pandemic A (H1N1) FS	Seasonal influenza FS	Non-influenza FS
* P < 0.05, significantly different from the corresponding values for the seasonal influenza FS group. ** P < 0.01, significantly different from the corresponding values for the seasonal influenza FS group. † P < 0.05, significantly different from the corresponding values for the non influenza FS group. †† P < 0.01, significantly different from the corresponding values for the non influenza FS group.
Total	90	80	252
Male	60 (66.7%)	54 (67.5%)	154 (61.1%)
Age (year: mean ± SD)	4.3 ± 2.8 *, ††	3.1 ± 2.2	2.1 ± 1.9
Patients aged ≥ 6 years	23 (25.6%) *, ††	9 (11.3%) †	11 (4.3%)
Body temperature at seizure occurrence (°C: mean ± SD)	39.3 ± 0.9	39.2 ± 0.7	39.3 ± 0.7
Positive history of seizures in first-degree relatives	25 (27.8%)	14 (17.5%)	40 (15.9%)
Time from fever to seizure occurrence
< 24 h (%)	83 (92.2%) **	56 (70%) ††	223 (88.5%)
> 24 h (%)	7 (7.8%) **	24 (30%) ††	26 (10.3%)
Negative previous FS history (%)	41 (45.6%) ††	48 (60%)	154 (61.1%)
Seizure manifestation: simple type (%)	82 (91.1%)	67 (83.8%)	216 (85.7%)
Seizure duration
Average (mean ± SD) min	4.8 ± 8.0	4.2 ± 6.2	4.0 ± 6.0
< 5 min	68 (75.6%) *, ††	70 (87.5%)	227 (90.1%)
5 - 15 min	7 (7.8%)	4 (5.0%)	9 (3.6%)
≥ 15 min	6 (6.6%)	5 (6.3%)	12 (4.8%)
Unknown	9 (10.0%)	1 (1.3%)	5 (2.0%)
Hospitalized patients	12 (13.3%)	7 (8.8%)	18 (7.1%)
Age of hospitalized patients	4.5 ± 2.5	2.9 ± 3.3	2.1 ± 2.8
WBC (µl; mean ± SD)	10,520.0 ± 3856.2 †	8,056.5 ± 3592.4 ††	12,877.5 ± 5771.5
CRP (mg/dl; mean ± SD)	0.61 ± 0.87	0.69 ± 0.82	0.99 ± 1.23

Table 2. Comparison of children with FSs in influenza A (H1N1) pdm, seasonal influenza, and non-influenza infection.

Pandemic A (H1N1) FS

Seasonal influenza FS

Non-influenza FS

* P < 0.05, significantly different from the corresponding values for the seasonal influenza FS group. ** P < 0.01, significantly different from the corresponding values for the seasonal influenza FS group. † P < 0.05, significantly different from the corresponding values for the non influenza FS group. †† P < 0.01, significantly different from the corresponding values for the non influenza FS group.

Total

252

Male

60 (66.7%)

54 (67.5%)

154 (61.1%)

Age (year: mean ± SD)

4.3 ± 2.8 *, ††

3.1 ± 2.2

2.1 ± 1.9

Patients aged ≥ 6 years

23 (25.6%) *, ††

9 (11.3%) †

11 (4.3%)

Body temperature at seizure occurrence (°C: mean ± SD)

39.3 ± 0.9

39.2 ± 0.7

39.3 ± 0.7

Positive history of seizures in first-degree relatives

25 (27.8%)

14 (17.5%)

40 (15.9%)

Time from fever to seizure occurrence

< 24 h (%)

83 (92.2%) **

56 (70%) ††

223 (88.5%)

> 24 h (%)

7 (7.8%) **

24 (30%) ††

26 (10.3%)

Negative previous FS history (%)

41 (45.6%) ††

48 (60%)

154 (61.1%)

Seizure manifestation: simple type (%)

82 (91.1%)

67 (83.8%)

216 (85.7%)

Seizure duration

Average (mean ± SD) min

4.8 ± 8.0

4.2 ± 6.2

4.0 ± 6.0

< 5 min

68 (75.6%) *, ††

70 (87.5%)

227 (90.1%)

5 - 15 min

7 (7.8%)

4 (5.0%)

9 (3.6%)

≥ 15 min

6 (6.6%)

5 (6.3%)

12 (4.8%)

Unknown

9 (10.0%)

1 (1.3%)

5 (2.0%)

Hospitalized patients

12 (13.3%)

7 (8.8%)

18 (7.1%)

Age of hospitalized patients

4.5 ± 2.5

2.9 ± 3.3

2.1 ± 2.8

WBC (µl; mean ± SD)

10,520.0 ± 3856.2 †

8,056.5 ± 3592.4 ††

12,877.5 ± 5771.5

CRP (mg/dl; mean ± SD)

0.61 ± 0.87

0.69 ± 0.82

0.99 ± 1.23