Int J Clin Pediatr

International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access

Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc

Journal website http://www.theijcp.org

Original Article

Volume 6, Number 1-2, June 2017, pages 1-7

Clinical and Laboratory Characteristics of Herpes Simplex Encephalitis in Children in Qena Governorate, Egypt

Figures

Figure 1.

Figure 1. Curve shows the sensitivity and specificity of EEG.

Figure 2.

Figure 2. Curve shows the sensitivity and specificity of CT.

Figure 3.

Figure 3. Curve shows the sensitivity and specificity of GCS < 10.

Tables

**Table 1.** Demographic Data of the Patients With Encephalitis
Demographic data	N = 50	%
Age
< 1 year	23	46.0
1 - 5 years	17	34.0
> 5 years	10	20.0
Sex
Male	29	58.0
Female	21	42.0
Residence
Urban	19	38.0
Rural	31	62.0
Socioeconomic status
Low	20	40.0
Middle	17	34.0
High	13	26.0

**Table 2.** Neurological Presentation of the Patients With Encephalitis
	N = 50	%
Lethargy	9	18.0
Behavioral changes	16	32.0
Seizure	30	60.0
Neck stiffness	21	42.0
Focal neurological finding	23	46.0
GCS < 10	26	52.0

**Table 3.** Demographic Characteristics in Relation to PCR
	PCR				No. of total cases (50)
	Positive (N = 28)		Negative (N = 22)
	No.	%	No.	%
Age (years)
< 1	12	52.2	11	47.8	23
1 - 5	10	58.8	7	41.2	17
> 5	6	60.0	4	40.0	10
P-value	NS
Sex
Male	11	37.9	18	62.1	29
Female	17	81.0	4	19.0	21
P-value	< 0.05*
Residence
Urban	9	47.4	10	52.6	19
Rural	19	61.3	12	38.7	31
P-value	NS
Socioeconomic state
Low	11	55.0	9	45.0	20
Middle	9	52.9	8	47.1	17
High	8	61.5	5	38.5	13
P-value	NS

**Table 4.** Neuroimaging and EEG Findings in Relation to Herpes Simplex Encephalitis According to PCR
Neuroimaging findings	PCR				No. of total cases (50)
	Positive (N = 28)		Negative (N = 22)
	No.	%	No.	%
CT
Abnormal findings*	12	80.0	3	20.0	15
Normal	16	45.7	19	54.3	35
P-value	< 0.05*
EEG
Abnormal findings*	22	55.0	18	45.0	40
Normal	6	60.0	4	40.0	10
P-value	NS

**Table 5.** Sensitivity and Specificity of PCR to GCS, EEG, and CT
	GCS < 10	EEG	CT
Sensitivity	57.69%	45.0%	80.0%
Specificity	45.83%	60.0%	54.29%
Positive predictive value	53.6%	81.8%	42.9%
Negative predictive value	50.0%	21.4%	86.4%
Area under curve (AUC)	0.518	0.525	0.671