International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access
Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc
Journal website http://www.theijcp.org

Case Report

Volume 9, Number 2, June 2020, pages 50-54

Autoimmune Hepatitis With Severe Hypergammaglobulinemia and Eosinophilia in a Child

Figures

Figure 1.
Figure 1. Abdominal axial CT shows hepato-splenomegaly associated with remarkable periportal collar sign (a) and edematous wall thickening of the gall bladder (b; arrow). CT: computed tomography.
Figure 2.
Figure 2. Liver wedge biopsy showing a chronic hepatitis pattern. (a) Hematoxylin and eosin staining, (b) CD3 staining, (c) CD38 staining and (d) CD20 staining (original magnification, × 100). IgG4 was scarcely stained and only a few eosinophils (2 - 3/hpf) are present at the portal area (figure not shown). IgG: immu‎noglo‎bulin G.
Figure 3.
Figure 3. Time course of laboratory data showing improvement up to 32nd week of treatment. First, serum IgG and ALT levels normalized, followed by γ-GTP and ChE. Units on the vertical axis: IgG: × 10 mg/dL; ALT/γ-GTP/ChE, U/L. IgG: immu‎noglo‎bulin G; ALT: alanine aminotransferase; γ-GTP: gamma-glutamyl transpeptidase; ChE: choline esterase.