Figure 1. Histogram showing distribution of the 71 doses of 4F-PCC in the cohort of 47 patients with the dose in units/kg on the x-axis and the number of doses on the y-axis. 4F-PCC: four-factor prothrombin complex concentration.
| International Journal of Clinical Pediatrics, ISSN 1927-1255 print, 1927-1263 online, Open Access |
| Article copyright, the authors; Journal compilation copyright, Int J Clin Pediatr and Elmer Press Inc |
| Journal website https://www.theijcp.org |
Original Article
Volume 13, Number 1, May 2024, pages 8-13
Prothrombin Complex Concentrate to Treat Coagulation Disturbances in Pediatric Patients With Intracranial Pathology Including Traumatic Brain Injury
Figure
Tables
| Parameter | Mean ± SD with range or number |
|---|---|
| SD: standard deviation. | |
| Number | 47 |
| Age (years) | 8.97 ± 6.78, 1 day to 18 years |
| Weight (kg) | 35.44 ± 27.11, 3.2 to 96.5 kg |
| Gender (male/female) | 29/18 |
| Etiology | N (%) |
|---|---|
| Intracranial hemorrhage | 24 (51%) |
| Increased intracranial pressure/hypoxic-ischemic encephalopathy | 13 (28%) |
| Traumatic brain injury | 7 (15%) |
| Hemorrhagic shock | 3 (6%) |
| Parameter | Dose (units/kg) | ||
|---|---|---|---|
| Range | 11 - 75 | ||
| Median | 26 | ||
| Mean ± SD | 30.4 ± 14.7 | ||
| IQR | 20.5 - 38.8 (18) | ||
| Dose (units/kg) | Frequency | ||
| Frequency is based on percentage of the total of 71 doses. 4F-PCC: four-factor prothrombin complex concentration; IQR: interquartile range; SD: standard deviation. | |||
| < 20 | 14 (20%) | ||
| 20 - 29 | 34 (48%) | ||
| 30 - 39 | 7 (10%) | ||
| 40 - 49 | 3 (4%) | ||
| 50 - 59 | 10 (14%) | ||
| ≥ 60 | 3 (4%) | ||
| Coagulation parameter | Parameter decreased | Corrected to normal value* | Value (s) before and after 4F-PCC** |
|---|---|---|---|
| *Percentage based on numbers that were high prior to 4F-PCC. **Paired t-test, P < 0.05 was considered significant. 4F-PCC: four-factor prothrombin complex concentration; INR: international normalized ratio; PT: prothrombin time; PTT: partial thromboplastin time. | |||
| INR | 78% | 38% | 2.4 ± 1.4 to 2.0 ± 1.5, P = 0.11 |
| PT | 74% | 1.6% | 25 ± 11 to 22 ± 11, P = 0.03 |
| PTT | 63% | 16% | 63 ± 48 to 70 ± 60, P = 0.36 |