Valproate-Induced Non-Hepatic Hyperammonaemic Encephalopathy: A Rare Complication of Chronic Valproate Therapy

Amit Agrawal, Rashmi Agrawal


Valproic acid can sometimes produce encephalopathy secondary to hyperammonemia without hepatic dysfunction, termed as valproate-induced hyperammonaemic encephalopathy (VHE). VHE is characterized by acute onset of impaired consciousness, lethargy, confusion, headache, vomiting, seizures and focal neurological deficits. Known risk factors include therapy with multiple antiepileptic drugs, presence of underlying inborn errors of metabolism, febrile states, and insufficient nutritional intake. We hereby, describe a case of VHE in a 10-year-old male child on long-term VPA therapy and no history of underlying liver disease. Encephalopathy reversed on withdrawal of VPA and L-carnitine therapy. We emphasize the need for early recognition, investigation, and treatment of this potentially life-threatening condition. 



Encephalopathy; Hyperammonemia; Valproic acid

Full Text: HTML PDF

Browse  Journals  


Journal of Clinical Medicine Research

Journal of Endocrinology and Metabolism

Journal of Clinical Gynecology and Obstetrics

World Journal of Oncology

Gastroenterology Research

Journal of Hematology

Journal of Medical Cases

Journal of Current Surgery

Clinical Infection and Immunity

Cardiology Research

World Journal of Nephrology and Urology

Cellular and Molecular Medicine Research

Journal of Neurology Research

International Journal of Clinical Pediatrics






International Journal of Clinical Pediatrics, quarterly, ISSN 1927-1255 (print), 1927-1263 (online), published by Elmer Press Inc.                     
The content of this site is intended for health care professionals.
This is an open-access journal distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License, which permits unrestricted
non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Creative Commons Attribution license (Attribution-NonCommercial 4.0 International
CC-BY-NC 4.0)

This journal follows the International Committee of Medical Journal Editors (ICMJE) recommendations for manuscripts submitted to biomedical journals,
the Committee on Publication Ethics (
COPE) guidelines, and the Principles of Transparency and Best Practice in Scholarly Publishing.

website:   editorial contact:
Address: 9225 Leslie Street, Suite 201, Richmond Hill, Ontario, L4B 3H6, Canada

© Elmer Press Inc. All Rights Reserved.

Disclaimer: The views and opinions expressed in the published articles are those of the authors and do not necessarily reflect the views or opinions of the editors and Elmer Press Inc. This website is provided for medical research and informational purposes only and does not constitute any medical advice or professional services. The information provided in this journal should not be used for diagnosis and treatment, those seeking medical advice should always consult with a licensed physician.