Febrile Seizures With Pandemic (H1N1) 2009 Virus Infection

Tatsuo Fuchigami, Emiko Momoki, Maki Hasegawa, Yuki Imai, Ayako Nakamura, Katsuya Saito, Teruaki Ishikawa, Chikako Arakawa, Koji Hashimoto, Yukihiko Fujita, Yasuji Inamo, Hideo Mugishima


Background: In April 2009, a novel influenza A (H1N1) pdm virus was identified in Mexico, and spread quickly around the world.

Methods: We treated 90 patients aged 0 - 14 years with influenza-associated febrile seizures due to this virus, who presented at our hospital between July 2009 and March 2010. We investigated the clinical characteristics of the patients. We also compared the clinical presentation of children with febrile seizures due to pandemic A (H1N1), seasonal influenza, and non-influenza infection.

Results: The average age of patients with febrile seizures and influenza A (H1N1) pdm was 4.3 years, which was significantly higher than that for seasonal influenza, 3.1 years, and non-influenza infection, 2.1 years.

Conclusions: There was no significant difference in neurological symptoms between the patients with febrile seizures due to seasonal influenza and 2009 pandemic influenza. However, febrile seizures with influenza A (H1N1) pdm occurred in older children compared with seasonal influenza and non-influenza infection.



Febrile seizures; Influenza; Pandemic influenza; Seasonal influenza; Influenza A(H1N1) pdm virus; Children; Neurological symptoms; Japan

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